WebThis product is a mouse antibody that recognizes human CRBN. It can be used in the following applications: WB, IHC, ELISA. Conjugation: NONE PE APC Biotin FITC HRP … WebCereblon (CRBN), a DCAFs (DDB1 and CUL4-associated factors), is a well-established protein associated with human mental retardation. Being a substra … Susceptibility of pentylenetetrazole-induced seizures in mice with Cereblon gene knockout BMB Rep. 2024 Sep;53(9):484-489.doi: 10.5483/BMBRep.2024.53.9.119. Authors Seung-Je Jeon 1
Rescue of Learning and Memory Deficits in the Human …
WebSep 6, 2024 · Binding of IMiDs to Cereblon (CRBN), the substrate receptor of the CRL4 CRBN E3 ubiquitin ligase, induces cancer cell death by targeting key neo-substrates for degradation. Despite this... WebMar 3, 2024 · Cereblon (CRBN) is a substrate receptor of the cullin-RING E3 ubiquitin ligase (CRL) complex that mediates the ubiquitination of several substrates. In this study, … cms person-centered planning
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WebMay 17, 2013 · Crbn KO mice fed an HFD show improved glucose homeostasis and insulin sensitivity. Crbn KO mice were largely protected from HFD-induced obesity and fatty liver; therefore, we next investigated their metabolic parameters. WebSep 22, 2024 · In this study, CRBN-KO mice exhibited decreased levels of stratum corneum hydration (SCH) and dermal collagen 1 expression, along with an elevated level of matrix metalloprotease 1 (MMP1). SCH is a hallmark of skin barrier function abnormalities. SCH levels in CRBN-KO mice decreased by more than 3 times, compared with those in wild … WebFeb 7, 2024 · CRBN knockdown mitigates lipopolysaccharide-induced acute lung injury by suppression of oxidative stress and endoplasmic reticulum (ER) stress associated NF … cmsp formulary