WebJul 9, 2009 · Methotrexate-induced neurotoxicity (MTX-Ntox) is a frequent complication of methotrexate (MTX) therapy for patients with both malignant and inflammatory diseases. ... Five patients with severe subacute MTX-Ntox (most with dysarthria and/or hemiplegia) were treated with 1-2 mg/kg oral dextromethorphan (DM), a noncompetitive antagonist of the … WebDec 10, 2024 · The manifestations of subacute methotrexate neurotoxicity are diverse and require vigilant management; nonetheless, symptoms are transient in almost all patients. …
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WebKeywords. Methotrexate, Neurotoxicity, Lymphoblastic lymphoma, Pseudo-stroke, Dextromethorphan Introduction. The acute lymphoblastic lymphoma (ALL) is the most common form of leukemia in children, being its treatment one of the leading causes of death associated to cancer [1,2].The therapeutic protocol in use to treat this disease in Porto's … WebDextromethorphan and Methylxanthines Might Be Useful in the Treatment of Methotrexate-Induced Neurotoxicity. Fernández-Fernández, Francisco José MD; Ameneiros-Lago, Eugenia MD; Lijó-Carballeda, Cristina MD; Sesma, Pascual PhD. Pediatric Emergency Care 33 (5):p 380, May 2024. DOI: 10.1097/PEC.0000000000001128. flight boutique park city ut
Dextromethorphan Article - StatPearls
WebMethotrexate-induced neurotoxicity (MTX-Ntox) is a frequent complication of methotrexate (MTX) therapy for patients with both malignant and inflammatory diseases. MTX-Ntox can occur after intrathecal MTX or after low-, intermediate-, or high-dose systemic administration: Symptoms can present in the acute, subacute, or late setting form, and … WebApr 11, 2016 · The MISS questionnaire embodies five elements: abdominal pain, nausea, vomiting, fatigue and behavioural symptoms. One-third of the RA patients exhibited MTX intolerance according to the MISS questionnaire. Out of which, the most recurring symptom was behavioural (44%) and least common being vomiting (11%). WebJul 15, 2024 · Methotrexate. Folic acid antagonist. Used as chemotherapeutic agent or DMARD . May be given orally, IV, or intrathecally. Neurotoxicity. Can occur anytime after … flightbox ads-b