Downregulation of gfap
WebJan 30, 2014 · We observed a phospho PPARγ (serine 112 (S112)) (p-PPARγ (S112))-mediated downregulation of GFAP in the MM-exposed astrocytes. We validated this using pure PPARγ agonist, troglitazone (TZ). As reported with MM, TZ induced astrocyte damage owing to reduced GFAP. WebApr 19, 2024 · The major discovery was the downregulation of synaptic glial genes that mitigate the HD phenotype, and the concept of compensatory versus pathogenic …
Downregulation of gfap
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WebJun 2, 2015 · We found downregulation of GFAP mRNA and protein in the mediodorsal thalamus and caudate nucleus of depressed suicides compared with controls, whereas … WebNational Center for Biotechnology Information
WebThe data strongly suggested that HCMV IE1 could modulate the expression of cellular genes that might play important roles in the pathogenesis of glial tumors, including glial fibrillary acidic protein, thrombospondin‐1, and p53. Human cytomegalovirus (HCMV) is a member of the β‐herpesvirus family, which has tropism for glial cells. It was recently reported that … WebJun 2, 2015 · Resveratrol Inhibits the Invasion of Glioblastoma-Initiating Cells via Down-Regulation of the PI3K/Akt/NF-κB Signaling Pathway . by Yuming Jiao. 1,2, Hao Li. 1,2 ... were treated with DMSO (vehicle) and 5 μM, 10 μM, and 20 μM RES for 48 h, respectively. CD133, Nestin and GFAP were investigated by Western blotting analysis. PC-12 lysate …
WebAs determined by gene and protein analysis, culture of the human Müller glial cell line MIO-M1 in the presence of TNF-α, causes downregulation of GFAP expression. Through … WebApr 6, 2011 · The inhibition of undesirable glial activity surrounding micturition-related pathways improved acute urinary dysfunction due to neurogenic bladder. In conclusion, …
WebGFAP: A gene on chromosome 17q21 that encodes a major class-III intermediate filament protein of mature astrocytes, which serves as a marker (in histopathology) to distinguish …
WebThis indicates the importance of the GFAP promoter and transcriptional response elements in responding to TNF-α during gliosis. In conclusion, the present study has identified the downregulation of GFAP expression by TNF-α in Müller glial cells as a target that could be further explored to control scarring of the human retina. health benefits for mom breastfeedingWebGlial Fibrillary Acidic Protein. Glial fibrillary acidic protein (GFAP) was first isolated in 1971 and is only found in glial cells of the CNS, constituting the major part of the cytoskeleton of astrocytes. GFAP is a biomarker for astroglial injury, as is S100β. Unlike S100β, GFAP is a brain-specific protein released after any brain injury ... health benefits for oatsWebSep 10, 2012 · As several transcription factors have been reported to be targets of curcumin [33], [34] we have investigated whether GFAP down-regulation may be mediated by a defective gene transcription. To this aim, U251-MG cells were transfected with a construct containing the GFAP promoter upstream the Luciferase reporter gene and added with 15 … golf outing rulesWebInvolvement of Normalized Glial Fibrillary Acidic Protein Expression in the Hippocampi in Antidepressant-Like Effects of Xiaoyaosan on Chronically Stressed Mice ... “Danzhi Xiaoyao San ameliorates depressive-like behavior by shifting toward serotonin via the downregulation of hippocampal indoleamine 2,3-dioxygenase,” Journal of ... golf outing save the dateWebGlial Fibrillary Acidic Protein. Glial fibrillary acidic protein (GFAP) was first isolated in 1971 and is only found in glial cells of the CNS, constituting the major part of the cytoskeleton of astrocytes. GFAP is a biomarker for astroglial injury, as is S100β. Unlike S100β, GFAP is a brain-specific protein released after any brain injury ... golf outings at thornberry creek at oneidaWebOn the other hand, the level of glial fibrillary acidic protein (GFAP), a marker of differentiated astrocyte, was upregulated upon differentiation condition, suggesting that cancer stem-like cell populations in U373 glioblastoma have morphological and molecular characteristics of cancer stem cells. ... Downregulation of the stemness of ... golf outings dayton ohioWebJan 1, 2024 · The downregulation of retinal Cx43 in GFAP-expressing cells compromises vasoreactivity of both arterioles and venules in response to an OPP decrease achieved via blood pressure lowering or IOP elevation. ... Here we used viral transfection and a glial fibrillary acidic protein (GFAP) promoter to downregulate glial Cx43 to evaluate its role … health benefits for onions