Tfrc knockin

Author: jhmz

August undefined, 2024

WebTransferrin Receptor Protein-1 (TFRC) is a cell surface receptor that binds ferric-iron-loaded transferrin in the bloodstream at high affinity to facilitate iron uptake into cells. TFRC is therefore an integral component of the body’s iron supply chain and general homeostasis. WebNormalized expression data for each known or novel expressed feature of 'TFRC' The following table summarizes the expression values of all known features of the gene ' …

Iron metabolism protein transferrin receptor 1 involves in cervical ...

Web26 Jan 2024 · In contrast to the previously reported hepatocyte Tfrc knockout mice, Tfrc fl/fl;Alb-Cre + mice exhibited slightly, but significantly, decreased hematocrit compared with Tfrc fl/fl;Alb-Cre − controls. Hemoglobin was also significantly reduced in Tfrc fl/fl;Alb-Cre + males, with a similar trend in females (Table 1). Tfrc fl/fl;Alb-Cre + mice also exhibited … WebTFRC Knockout Cell Line-HeLa Cat.No. CSC-RT1891 Description HeLa -TFRC (-/-) is a stable cell line with a homozygous knockout of human TFRC using CRISPR/Cas9. Host Cell HeLa Shipping 1 vial of knockout cell line and 1 vial of wildtype cell line Storage Liquid nitrogen Gene Information Gene Name TFRC Gene Symbol TFRC Gene ID 7037 Q&A oy ticket\u0027s

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Web4 Apr 2024 · Tfrc transferrin receptor [ (house mouse)] Gene ID: 22042, updated on 28-Feb-2024 Summary This gene encodes a cell surface receptor necessary for cellular iron … WebHeLa -TFRC(-/-) is a stable cell line with a homozygous knockout of human TFRC using CRISPR/Cas9. Host Cell. HeLa. Shipping. 1 vial of knockout cell line and 1 vial of wildtype … Web5 Jul 2024 · The Tfrc AKO mice were also protected from obesity induced by a high-fat diet (HFD). Compared with control mice, Tfrc AKO mice had increased iron storage in the liver and a lower adipose mass ... oy town\\u0027s

Transferrin receptor 1 controls systemic iron homeostasis by fine ...

Frontiers WDR45 Mutation Impairs the Autophagic Degradation …

Web21 Mar 2024 · TFRC (Transferrin Receptor) is a Protein Coding gene. Diseases associated with TFRC include Immunodeficiency 46 and Combined Immunodeficiency.Among its … WebA “transferrin binding site” as used herein refers to regions in the helical and protease-like domain of a TfR protein that mediate binding of transferrin, e.g., iron-bound transferrin, to … oy thimble\u0027sWeb8 Jun 2024 · Background and Aims: Iron deficiency (ID) is a frequent extra-intestinal manifestation in patients with Inflammatory Bowel Disease (IBD), who often do not respond to iron supplementation. Iron is a cofactor for hydroxylases that suppress the hypoxia-inducible factor-1α (HIF1α), a transcription factor regulating iron homeostasis. We … oy thicket\\u0027s

"Web30 Jun 2016 · Conditional deletion of Tfrc in NCCs leads to mandible hypoplasia. (a) Expression pattern of Tfrc in NCCs-derived cells is detected by immunofluorescent staining of Tfrc (red) and AP-2α (green ... " - Tfrc knockin

Tfrc knockin

Tfrc Knockout Mouse Research Models Taconic Biosciences

Web2 May 2024 · The TfR-mediated incorporation of JR-141 was confirmed by using human fibroblasts in vitro. When administrated intravenously to hTfR knockin mice or monkeys, … Web27 Oct 2024 · Results presented Fig. 5c demonstrate that TFR1 (CD71) and iron regulatory protein 1 (IRP1) are downregulated in the presence of HSA-heme in Jurkat T cells, …

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Web5 Nov 2024 · The IREB2 gene encodes an iron-responsive element-binding protein (IRP) that regulates the expression of proteins involved in iron metabolism by binding to iron-responsive elements in the mRNAs of target genes, which include the transferrin receptor (TFRC; 190010) as well as the heavy and light ferritin chains (FTH1, 134770 and FTL, … WebFig. 1. The central biochemical event of ferroptotic cancer cell death. The central biochemical event of ferroptosis is involved in iron accumulation and lipid peroxidation, which leads to oxidative injury and cell death. ROS, reactive oxygen species. Iron is an important trace element in many species.

WebSerum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of … Web23 Jan 2024 · To obtain TFRC knockdown cells, short hairpin RNA (shRNA) transfection method was used to transfect it into HeLa cells. The TFRC -shRNA sequence (5ʹ-GCT GGT CAG TTC GTG ATT AAA-3ʹ) was introduced into pGFP-B-RS vectors (Origene, Peking, China), which were digested by BamH I and Hind III enzymes.

Web17 Mar 2024 · The transferrin receptor 1 (TfR1), also known as cluster of differentiation 71 (CD71), is a type II transmembrane glycoprotein that binds transferrin (Tf) and performs a … Web9 Apr 2024 · TFRC upregulation promotes ferroptosis in CVB3 infection via nucleus recruitment of Sp1. Iron metabolism protein transferrin receptor 1 involves in cervical cancer progression by affecting gene expression and alternative splicing in HeLa cells. Host receptor-targeted therapeutic approach to counter pathogenic New World …

Web15 Aug 2014 · The assay location is chr.16:32626732 on NCBI build 37. It has a 91 bp amplicon that maps within exon 17 of the Tfrc gene. TaqMan™ Copy Number Reference Assay, Mouse, Tert is an alternative reference assay; it is recommended in the event that the Tfrc assay functions poorly with a sample because of chromosomal aberrations or other …

Web3 May 2024 · TfRC was accumulated after the inhibition of autophagy by treatment with autophagic inhibitor chloroquine or knockdown of ATG2A. The intracellular iron content was increased in cells overexpressing TfRC or mutant WDR45, however, ferritin H (FTH) chain was decreased. oy thimble\\u0027sWeb19 May 2024 · MYCN is a regulator of GPX4-dependent ferroptosis. To study MYCN-dependent cellular processes in NB, we examined a collection of 147 genes essential for the survival of MYCN-amplified NB cells 17 ... jeffrey miller of rocky riverWebTransferrin receptor 1. Transferrin receptor protein 1 ( TfR1 ), also known as C luster of D ifferentiation 71 ( CD71 ), is a protein that in humans is encoded by the TFRC gene. [5] [6] … jeffrey mills solicitorsWeb16 Apr 2024 · The TFRC-sh, TFRC-OE, SLC7A11-sh, and SLC7A11-OE plasmids were purchased from GeneChem (Shanghai, China). The plasmids with truncated TFRC promoter regions that were cloned into pGL3 were ... oy tribe\\u0027sWeb13 May 2024 · Transferrin receptor (TFRC) is the major mediator for iron entry into a cell. Under excessive iron conditions, TFRC is expected to be downregulated via the iron regulatory protein and the iron-responsive element machinery to … oy township\u0027sWebTFRC INFORMATION. Proteini. Full gene name according to HGNC. Transferrin receptor. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. TFRC (CD71, p90, TFR1) Protein classi. Assigned HPA protein class (es) for the encoded protein (s). oy tress\u0027sWeb28 Mar 2024 · This is the website of the Time For Real Change in UNISON campaign. UNISON is crying out for real change. We are rank and file UNISON activists determined to make our union democratic, transparent and successful - a fighting union that delivers for its members. Find out more about us and get involved with our campaign on our website. jeffrey mills solicitors st neots