Trimethyltin effect on rat
WebSep 1, 1985 · Male Wistar (Porton) rats were dosed by gavage with trimethyltin chloride in arachis oil at doses of 3, 6 and 10 mg kg. Water consumption and urine production were … WebGorini. "Effect of CDP-choline on age-dependent modifications of energy- and glutamate-linked enzyme activities in synaptic and non-synaptic mitochondria from rat cerebral cortex", Neurochemistry International, 2012 Crossref Koda, T.. "Protective effect of rutin against spatial memory impairment induced by trimethyltin in rats", Nutrition ...
Trimethyltin effect on rat
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WebMar 22, 2024 · Application of trimethyltin (TMT) to rats represents a promising model replicating ... and GABAA receptor potentiator midazolam would be associated with an … WebTrimethyltin is an organometallic compound, described to be neurotoxic and to trigger neuroinflammation and oxidative stress. Previous studies associated TMT with the perturbation of mitochondrial fu
WebTrimethyltin hese anatomical and behavioral indings have made TMT- (TMT) is an organotoxic compound with potent neuro- intoxicated rats an attractive model for degenerative diseases toxicant efects which is regarded as being particularly such as AD, the most common cause of dementia [9, 10]. useful for studying the response to injury on … WebMar 22, 2024 · Research of treatment options addressing the cognitive deficit associated with neurodegenerative disorders is of particular importance. Application of trimethyltin (TMT) to rats represents a promising model replicating multiple relevant features of such disorders. N-methyl-D-aspartate (NMDA) receptor antagonists and gamma-aminobutyric …
WebAug 30, 2016 · To evaluate the effect of TMT on cochlear function, the CAP was recorded with the facial nerve canal electrode ... Wonderlin W.F., Bercegeay M. The trimethyltin syndrome in rats. Neurobehav. Toxicol. Teratol. 1982; 4:127–133. [Google Scholar] Fechter L.D., Clerici W.J., Yao L., Hoeffding V. Rapid disruption of cochlear ... WebFor example, a particular behavior, such as activity in an open field, may be changed in a dose-related fashion by drugs that have a recognized clinical effect in psychiatric …
WebJun 11, 2024 · To measure the effect of regulatory T cell transfer on spatial learning and memory ability in TMT-induced mice, ... et al. Expression of EMAP-II by activated monocytes/microglial cells in different regions of the rat hippocampus after trimethyltin-induced brain damage. Exp Neurol. 2002; 177 (1):341–346. doi: 10.1006/exnr.2002.7985.
WebTo assess the nature and extent of behavioural, biochemical and histological changes induced by trimethyltin (TMT), rats were treated with a single injection of TMT over a … nallawilli office waresWebtained from trimethyltin treated rats. However, ab- solute measures, such as hippocampus volume or number of cells of this anatomic structure were not reported. Differences in cellular losses were noted between medial and lateral sagittal sections sug- gesting a focal effect of trimethyltin on the hippo- campus. med spa nurse practitioner jobsWebAug 1, 1986 · Trimethyltin (TMT) is commonly used to induce neurodegeneration in mice and rats; however, only scarce data of in vivo magnetic resonance (MR) spectroscopy and imaging characterizing TMT neurotoxicity are available. Our aim was to assess brain metabolite changes and brain atrophy by in vivo MR in the rat model of neurodegeneration … nallathoru kudumbam song lyricsWebAfter a single gastric dose of 4.0 mg/kg trimethyltin chloride (2.4 mg tin/kg) to rats, the blood and brain concn of trimethyltin (expressed as tin) were 39 ug/ml and 1.3 ug/g, respectively, while ... after the 4th weekly dose of 4.0 mg/kg the corresponding concn were 120 ug/ml and 3.5 ug/g.In the marmoset treated with 3.0 mg/kg trimethyltin chloride (1.8 … nallathur templeWebAug 15, 2002 · In contrast, rates of respiration by liver mitochondria isolated from rats treated in vivo with trimethyltin chloride, following prior treatment with clofibrate, were … med spa northwestern chicagoWebLarge pyramidal neurons of the hippocampus of a rat treated with trimethyltin (TMT) (7.3 mg TMT/kg, po) and killed 7 days later to show severe neuronal ... dorsal root ganglia, olfactory cortex, retina, and inner ear. TMT is increasingly exploited as a model neurotoxicant in rats to study the impact of chemical-induced altered hippocampal ... medspan researchWebJul 11, 2024 · 1. Introduction. Trimethyltin (TMT) intoxication is regarded as an appropriate model of chronic neuronal degeneration associated with cognitive impairment, and is … nallawilli technology